Results showed a tendency to decrease the 3R/4R tau ratio 1.17-fold (p = 0.3194), with WB (Figure 6C), or decrease 1.73-fold (p = 0.0912) with RT-PCR (Figure 6D), at Initial AD stages, which reverse correlates with PrPC, which showed a 1.17-fold increase (* p = 0.0316) with WB (Figure 6A), or a 2.55-fold increase (* p = 0.0441) with RT-PCR (Figure 6B), when compared to non-degenerative (non-AD) controls. The gene discussed is PRNP; the disease is Alzheimer disease.