T2D patients with CVD (n = 45, 67 ± 7 years, 79% males) showed lower circulating OGN levels compared to T2D patients without CVD (n = 91, 65 ± 8 years, 47% males): (17.88 (15.39–20.38) ng/mL vs. 21.15 (19.44–22.86) ng/mL). Here, OGN is linked to type 2 diabetes mellitus.