We found that, in addition to age (OR = 1.08; 95% CI (1.01/1.15); p = 0.021), the serum OGN level was an independent estimator of impaired kidney function risk (OR = 1.07; 95% CI (1.01/1.14); p = 0.029) in T2D patients. The gene discussed is OGN; the disease is type 2 diabetes mellitus.