We analyzed the cohort of 547 EEC patients in TCGA (Table S1) and identified 38 somatic mutations of the IK gene, including six patients with R93fs deletion (c_267_267delines-GA), three patients with stop-gain nonsense mutations, and others with missense mutations (Figure 1a and Table S2). The gene discussed is IK; the disease is exstrophy-epispadias complex.