In the present study, the PLA data indicated that KCF18 could simultaneously inhibit more than 70% binding of TNF-α to TNFR1, more than 80% binding of IL-1β to IL-1R, and approximately 70% binding of IL-6 to IL-6R in the liver tissues of mice with endotoxemia. This evidence concerns the gene TNFRSF1A and serum lipopolysaccharide activity.