For example, different authors have shown that IL-6 production is elevated by IL-4 or IFN-γ in keratinocytes, especially in a histamine-enriched milieu [18,19]; IL-6 may play a dual role in autoimmunity by contributing to the humoral response through the polarization of Th2 and B lymphocytes [20] and promoting Th1/Th17 differentiation [21]. The gene discussed is IL6; the disease is Autoimmunity.