Similarly, cytokines released by damaged epidermis, such as thymic stromal lymphopoietin (TSLP) and IL-33, may trigger the pruritogenic and humoral response in AD patients (Th2-mediated), mediated by elevated levels of IL-4, IgE, and histamine (see the review by Corren and Ziegler [13]). Here, IL4 is linked to Alzheimer disease.