We found that the frequency of A allele and AA homozygotes for REN rs2368564 polymorphism was significantly higher in the group of patients with ISR, and the minor allele was associated with the development of in-stent restenosis in patients with stable CAD after implantation of the DES (for AA genotype OR 4.062; CI 1.758–9.382). Here, REN is linked to coronary artery disorder.