Finally, the administration of GDNPs 2 to AOM/DSS mice treated with the carcinogen Azoxymethane and DSS (AOM/DSS group), which recapitulate CAC, decreased Lcn-2 levels, the number of tumors per mouse, and IL-6 and IL-1β expression compared with the AOM/DSS group [48]. The gene discussed is LCN2; the disease is infectious otitis media.