MAPT and Alzheimer disease: Common features of AD are aberrant production and deposition of β-amyloid (Aβ) peptides, either in Aβ40 or Aβ42 fragments and Tau protein hyperphosphorylation aggregates (neurofibrillary tangles), disruption of normal autophagic processes, generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), and cell death [3,4].