Despite the absence of Aβ plaques, as observed by immunohistochemical sections, we aimed to determine by Western blotting if there were changes in Tau protein activity in the hypothalamus, as its hyperphoshorylation that leads to formation of toxic microtubule neurofibrillary tangles (NFTs), a hallmark of AD [5]. The gene discussed is MAPT; the disease is Alzheimer disease.