In a study by Stanisławowska et al. in children with type 1 diabetes, the analysis of Tregs cells in peripheral blood revealed a lower percentage and the absolute number of CD4+Foxp3+ regulatory T-cells compared to controls; on the contrary, a higher frequency and absolute number of CD4+IL17A+ Th17 cells was demonstrated in the patient group [53]. Here, CD4 is linked to type 1 diabetes mellitus.