CRP and type 1 diabetes mellitus: In a subset of the DCCT/EDIC cohort, where biomarkers were measured at four time points over 20 years in 886 T1DM patients, IL-6, along with tumor necrosis factor receptor-1 and -2, active and total plasminogen activator inhibitor-1 (PAI-1), adhesion molecules and acute-phase reactants, namely fibrinogen and C-reactive protein (CRP), were increased throughout the study period [75].