IGF1R and colorectal carcinoma: Interestingly, treatment of oxaliplatin-resistant colorectal cancer (CRC) cells, but not naïve cells, with IGF1R inhibitors (either ganitumab, a monoclonal antibody, or AEV-541, a tyrosine kinase inhibitor) promoted IGF1R nuclear internalization and PIAS3 inhibition decreased cytoplasm–nuclear IGF1R trafficking [47].