CD8A and metabolic dysfunction-associated steatohepatitis: For example, the chronic activation of CD8 T cells in NASH induces tissue damage and NASH progression, and, at the same time, activates immunosuppressive types of machinery and promotes T cell exhaustion, leading to reduced activity of CD8 T cells, surveillance evasion of tumor-initiating cells, and, subsequently, enhanced immunosuppression driven by cancer cells.