These pathways involve AMP-activated protein kinase (AMPK), fructose 1,6-bisphosphatase (FBP1), adenylate cyclase (AC), acetyl CoA carboxylase (ACC), and others, with many among them having an additional role in NASH pathogenesis and hepatocarcinogenesis. This evidence concerns the gene FBP1 and metabolic dysfunction-associated steatohepatitis.