Some of the genes relevant to metabolic problems, we have seen in other pulmonary hypertension models are uncoupling protein 2 (UCP2), its loss is associated with PAH [24], downregulated in KCNK3 cells; cytochrome B-245 alpha chain (CYBA), required for some modes of superoxide production [25] is increased; oxidative stress response gene, glutathione peroxidase 7 (GPX7) [26] is increased; of course, there are 25 other lipid response-related genes (Figure 1A). The gene discussed is KCNK3; the disease is pulmonary arterial hypertension.