By conducting transwell migration and invasion assays using cathepsin L-overexpressed, platyphyllenone-treated cells, we observed that overexpression of cathepsin L significantly increased the migration and invasion of oral cancer cells, and that the anti-migratory/anti-invasive effects of platyphyllenonewere also diminished by cathepsin L overexpression (Figure 7E,F). Here, CTSL is linked to lip and oral cavity carcinoma.