TGFB1 and chronic hepatitis C virus infection: Upon any liver injury in general, and chronic hepatitis C in particular, high levels of TGF-β1 and -β2 are secreted in the space of Disse by hepatocytes and neighboring cells [57,66], fueling fibrogenesis [34,189] (Figure 2), whereas TGF-β3 was reported as an antifibrotic cytokine in the liver.