Eicosanoids derived from n-6 PUFAs influence the synthesis of pro-inflammatory cytokines, i.e., interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), which participate in the development of such skeletal disorders as osteopenia, osteoporosis, or arthritis [8]. The gene discussed is TNF; the disease is Arthritis.