Figure 1 is a volcano plot of identified metabolites that demonstrates fold change, specifically that 44 metabolites were decreased when comparing Hemangiosarcoma vs. Control and 60 were increased. Metabolites in red include bradykinin, C3 and fibrin degradation products (FDPs). Metabolites in green are bile acids, orange are gamma glutamylated amino acids and yellow are anti-inflammatory lipids, steroid derivatives and a gut-derived phenol. Supplementary Materials Tables S1–S3 list identified metabolites that were unchanged, increased and decreased when comparing Hemangiosarcoma vs. Control. The gene discussed is KNG1; the disease is angiosarcoma.