The median serum levels of AFP, PIVKA-II, GPC-3, adiponectin and IL-6 were significantly higher in patients with HCC compared to those without tumor (all p < 0.001); only the plasma leptin values were not different between the two groups of patients (p = 0.649) (Table 2 and Figure 1). The gene discussed is GPC3; the disease is hepatocellular carcinoma.