Glypican-3 (GPC-3) is an oncofetal protein normally not expressed in the livers of healthy adults; so far, the available data on the performance of serum GPC-3 for HCC detection are conflicting and mainly confined to patients chronically infected with the hepatitis B virus (HBV) or hepatitis C virus (HCV) [21]. Here, GPC3 is linked to hepatocellular carcinoma.