BRIP1 and serous adenocarcinoma: It has been reported that ~18% of OC, particularly high-grade serous adenocarcinoma, is caused by germline genetic variants such as BRCA1/2, BRCA1-interacting protein C-terminal helicase 1 (BRIP1), and RAD51 paralog D (RAD51D) [5,6,7,8].