Besides CAFs, tumor-associated macrophages (TAMs), as myeloid derived suppressor cells, contribute to an immunosuppressive microenvironment and support tumor growth as they are a source of immunosuppressive cytokines (e.g., CCL17, CCL18 and CCL22) and tumor promoting growth factors (VEGF-A, TNF-α) [159,169,170,171]. The gene discussed is TNF; the disease is neoplasm.