After 5 days of coculture, a similar increase in Nanog mRNA levels could be observed through hyperglycemia and normoglycemic coculture with M1 macrophages, while hyperglycemic coculture with macrophages remarkably had the opposite effect on the benign cells and led to 0.6-fold reduced mRNA levels (Figure 3A). The gene discussed is NANOG; the disease is Hyperglycemia.