KRAS and Insulin resistance: However, Mauer et al. showed that the expression levels of genes linked to inflammatory processes and insulin resistance were significantly higher in liver and white adipose tissue of mice with an IL-6 deficiency in myeloid cells than in mice with intact IL-6 activity [50], which is consistent with our observations that in cocultured H6c7-kras cells mRNA levels of EMT- and CSC-inducing pro-inflammatory mediators were elevated upon Tocilizumab treatment (data not shown).