It was widely demonstrated that chronic overnutrition elicits an inflammatory response leading to systemic and tissue-specific low-grade inflammation through the release of proinflammatory cytokines, including interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), as well as production of reactive oxygen species (ROS), which directly attenuate insulin signaling in insulin-sensitive tissues (Scheme 1) [8,9,10]. The gene discussed is TNF; the disease is overnutrition.