In contrast, intratumoral concentrations of the tumor-promoting factors GM-CSF (Figure 4E, Kruskal–Wallis test, KW = 17.95, p = 0.001) and IL-6 (Figure 4F, Kruskal–Wallis test, KW = 13.60, p = 0.004) were significantly reduced in therapy-treated OB-RES mice at day 21 post-tumor challenge. This evidence concerns the gene CSF2 and neoplasm.