Moreover, NLRP3 inflammasome-derived IL-1β and IL-18 play a protective role against oxazolone-induced colitis [44], and a hyperactive NLRP3 inflammasome (such as that in the Nlrp3 R258W mutant mouse line) confers strong resistance to experimental colitis/CRC [45]. This evidence concerns the gene NLRP3 and colorectal carcinoma.