NLRP3 inflammasome activation has been demonstrated to promote inflammation-induced carcinogenesis in head and neck squamous cell carcinoma (HNSCC) [85], and P2 × 7R and NLRP3 have been found to be overexpressed in HNSCC in association with increased survival and invasiveness [86]. Here, NLRP3 is linked to head and neck squamous cell carcinoma.