Celastrol, a natural triterpene, has been demonstrated to be an important inhibitor of the NF-kappaB signaling pathway [174] and of the NLRP3 inflammasome, and suppressing caspase-1 activation and IL-1β secretion prevents DSS-induced colitis [175] and reduces the ability of macrophages to stimulate the migration and invasion of melanoma cells [152]. This evidence concerns the gene CASP1 and melanoma.