The protective role of NLRP3 was suggested by experiments that showed that azoxymethane-dextran sodium sulfate (AOM-DSS) mice deficient in inflammasome components, including Nlrp3, Asc, Caspase-1, Caspase-11, IL-18 and IL-18r, were more susceptible to CRC than those without deficiencies and exhibited accelerated tumor growth accompanied by attenuated levels of IL-1β and IL-18 [40,41,42,43]. The gene discussed is IL18; the disease is neoplasm.