IL1B and pachyonychia congenita: In line with this notion, PC cell lines and tumor cell-conditioned macrophages are able to activate ASC and to induce the release of IL-1α and IL-1β which are crucial for the secretion of thymic stromal lymphoprotein (TSLP) by cancer-associated fibroblasts (CAFs), promoting Th2 inflammation [106] and increasing NF-kappaB activity and survival [107].