Other strategies have used the established pharmacologic and physiologic principles to ameliorate the condition of diseases such as non-familial pulmonary hypertension [197] by SB-mediated delivery of the endothelial nitric oxide synthase (eNOS) gene to restore the physiologic arterial pressure, and age-related macular degeneration (AMD) [128,198,199] by supplementation of the pigment epithelium-derived factor (PEDF) gene to restore the angiogenic/antiangiogenic balance in the retina. This evidence concerns the gene NOS3 and age-related macular degeneration.