Consequently, inhibition of HIF-1α production results in reduced angiogenesis, thereby, reducing tumor development which was observed in vitro in human hepatoblastoma cells transfected with reporter genes for hypoxia-inducible expression of firefly luciferase (Hep3B-c1), CD133 positive human glioma stem cells (GSC), and human glioma cells (U-87MG) [119,120,121]. Here, HIF1A is linked to central nervous system cancer.