NFKB1 and Fulminant hepatitis: In addition, intravenous administration of Man-S-α-CDE (G3, DSC2, DSM4)/sip65 complex had the potential to induce the in vivo RNAi effect by significant suppression of mRNA expression of NF-κB p65 and inflammatory cytokines in the liver of fulminant hepatitis model mice induced by LPS/D-galactosamine (D-Gal) without any significant side effects.