In MG-63 and Saos-2 human osteosarcoma cells, cisplatin and anti-GD2 mAb 14G2a dose-dependently induced endoplasmic reticulum (ER) stress-associated apoptosis by activating the protein kinase RNA-like ER kinase (PERK) ER stress pathway by synergistically inducing phosphorylation and activation of PERK [86]. The gene discussed is WEE1; the disease is osteosarcoma.