Concerning BrCa and PrCa cells, NF-κB and STAT3 are associated with premetastatic niche formation and migration and metastasis to the bone, as well as growth within the bone, at least partially by stimulating RANKL and PTHrP production, thereby accelerating tumor cell-promoted osteoclastogenesis [165,166,167,168,169,170]. The gene discussed is TNFSF11; the disease is neoplasm.