In addition, the most common cause of HSP involving variants in spastin (SPG4) has a well-documented role in interacting with the ESCRT-III complex-associated endosomal protein CHMP1B [26,27] via an MIT domain (contained within microtubule interacting and trafficking molecules) [28], also present in spartin (SPG20) [29], another HSP-associated molecule [30,31]. Here, SPAST is linked to hereditary spastic paraplegia.