Similar results were observed when patients with B-ALL were analyzed independently, with patients who carried the HLA-C*04 allotype showing a significant reduction in HLA-C expression (6903 ± 1412 vs. 12,026 ± 1581 MFI, p = 0.019) compared to patients with other C2-epitope allotypes (Figure 5). Here, HLA-C is linked to acute lymphoblastic leukemia.