Alterations in cadherins, vascular endothelial growth factors (VEGFs), matrix metalloproteinases (MMPs), and thrombospondin-1(TSP-1), i.e., factors involved in remodeling the extracellular matrix and that promote tumor angiogenesis, are more common in MIBC (T2–T4) and also contribute to nodal metastasis, with post-cystectomy recurrences that are higher in patients with MIBC and with a poorer prognosis [17]. This evidence concerns the gene THBS1 and neoplasm.