GFAP and Alzheimer disease: The experimental study showed that compared with the WT group, the expression of GFAP in the hippocampi of the 3×Tg AD group increased significantly, indicating that the damage to hippocup tissue in the 3×Tg AD group was obvious, the ascension was active compared with the 3×Tg AD group, and the expression of hippocome GFAP in the berberine group was significantly reduced, indicating that the berberine group inhibited the excessive growth of AD mice AS.