RBFOX3 and Alzheimer disease: In the BBR-treated 3×Tg AD group, compared with the 3×Tg AD group, the expression of caspaes-3 in the hippocampus was significantly lower (Figure 3G, p < 0.01), and the expression of NeuN was significantly higher (Figure 3F, p < 0.01), both of which were closer to the level observed in WT group.