As such, of the eight candidate mRNAs (uromodulin, SLC12A1, NDUFB2, OAZ1, PPARGC1A, NFE2L2, CD24 and SMAD1) measured in uEVs of DKD, chronic kidney disease, T2DM, nondiabetic obese, and healthy controls, uromodulin was the most expressed transcript in mild and severe DKD, and significantly increased when compared to healthy controls [80]. The gene discussed is SMAD1; the disease is diabetic kidney disease.