In addition, using a putative diagnosis biomarker for COPD, YKL-40 [120,121], combined assessment of serum EDN and YKL-40 revealed that a subset with both high serum EDN and YKL-40 levels was 45% in ACO, 14% in asthma and 30% in COPD (OR 3.85 (95% CI, 2.35–6.36); sensitivity, 45.2%; specificity 82.4%) [119]. The gene discussed is RNASE2; the disease is asthma.