Examples for that are pathways in cancer, cell cycle, viral carcinogenesis, ubiquitin-mediated proteolysis, apoptosis, FoxO signaling pathway, p53 signaling pathway, glioma genesis, transcriptional misregulation in cancer, ErbB signaling pathway, EGFR tyrosine kinase inhibitor resistance, PI3K–Akt signaling pathway, and neurotrophin signaling pathway. This evidence concerns the gene TP53 and central nervous system cancer.