HIF-1α can induce pluripotent stem cell inducers, such as OCT4, NANOG, SOX2, KLF4, c-MYC, and microRNA-302, in 11 cancer cell lines (derived from prostate, brain, kidney, cervix, lung, colon, liver, and breast cancers) [105]. This evidence concerns the gene POU5F1 and breast cancer.