CD44 elevates chemoresistance and invasion activity through a signal transducer and activator of transcription 3 (STAT3)-dependent mechanism, and it influences angiogenesis and immunosuppression in the tumor microenvironment via the secretion of various angiogenic factors and cytokines, including vascular endothelial growth factor and interleukin 6 [38]. Here, CD44 is linked to neoplasm.