The LmnaG609G HGPS mouse model, generated in 2011 by the López-Otín laboratory, was the first mouse model to express progerin due to aberrant splicing of the endogenous Lmna gene, resulting from the introduction of the 1827C>T (p.G609G) mutation, which is equivalent to the human mutation found in HGPS patients [45]. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.