In contrast, heterozygous G608G BAC and LmnaG609G/+ mice are useful tools for analyzing progerin-induced vessel calcification, whereas Apoe−/−LmnaG609G/G609G and Ldlr−/−LmnaG609G/G609G mice are suitable models for the study of HGPS-associated atherosclerosis. The gene discussed is LMNA; the disease is atherosclerosis.