LmnaG609G/G609G mice show defective endothelium-dependent aortic dilation in response to acetylcholine, a clear sign of endothelial dysfunction [50,57], prompting interest in progerin-induced endothelial alterations and their potential role in the development of the HGPS-associated cardiovascular phenotype. The gene discussed is LMNA; the disease is endothelial dysfunction.