APOE and atherosclerosis: In the context of Apoe deletion, Apoe−/−LmnaLCS/LCSSM22αCre mice develop similar vascular alterations to those found in Apoe−/−LmnaG609G/G609G mice, including VSMC depletion, adventitial thickening, and increased atherosclerosis burden [53], all of which are also prevented by treatment with the ER stress-targeting chaperone TUDCA [58].