APOE and aortic atherosclerosis: Similar to LmnaG609G/G609G mice, Apoe−/−LmnaG609G/G609G mice show postnatal growth defects, VSMC loss in the aortic arch, cardiac electrical anomalies, and reduced lifespan compared to Apoe−/−Lmna+/+ controls; however, Apoe−/−LmnaG609G/G609G mice also show adventitial thickening, accumulate fluorescently-labeled human low-density lipoproteins (LDLs) in the medial layer of atheroma-free aortic regions, and develop aggravated aortic atherosclerosis without evidencing higher serum cholesterol or LDL than Apoe−/−Lmna+/+ mice.