Consistently, a knockdown of CCN3 was found to decrease bone metastasis of prostate cancer cells since CCN3 upregulates the expression of the pro-migratory intercellular adhesion molecule 1 (ICAM-1) and promotes migration via AKT, NFKB, and other pathways [113]. The gene discussed is NFKB1; the disease is Familial prostate cancer.