Bone marrow stromal cell-derived C-C motif chemokine 5 (CCL5), also known as the chemotactic cytokine RANTES, was shown to induce migration and invasion of hepatocellular carcinoma cells via the PI3K/AKT pathway and, therefore, could promote bone metastasis [165]. The gene discussed is PIK3CA; the disease is hepatocellular carcinoma.