Furthermore, inhibition of the chaperon protein heat shock protein 90 (Hsp90) with 17-N-Allylamino-17-demethoxygeldanamycin (17AAG) was shown to activate AKT in an Src-dependent way in osteoclasts and, thus, promotes osteoclastogenesis as well as increases the intraosseous tumor growth of prostate cancer cells after intratibial inoculation [141]. Here, AKT1 is linked to Familial prostate cancer.