We finally identified 123 publications dealing with AKT in bone metastasis of one or multiple solid tumors (breast cancer: 52 publications; prostate cancer: 50 publications; lung cancer: 10 publications; malignant melanoma: 3 publications; renal cell carcinoma: 3 publications; bladder cancer: 1 publication; hepatocellular carcinoma: 2 publications; colorectal cancer: 1 publication; gastric cancer: 2 publications; oral squamous cell carcinoma: 1 publication; thyroid cancer: 1 publication). This evidence concerns the gene AKT1 and Familial prostate cancer.