As stated above, Shi et al. and Wang et al. reported a contribution of AKT in the initiation stage of breast and prostate cancer bone metastasis by facilitating the EMT in prostate cancer cells or mediating the stimulatory effect of E-N-heterotypic adherens junctions during the colonization of the osteogenic niche in breast cancer [54,102]. This evidence concerns the gene AKT1 and Familial prostate cancer.