The systematic review of the studies [27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65] carried out in children with IBDs treated with TNF-α agents published between 2000 and 2012 concluded that infection incidence was only slightly higher than that usually found in healthy subjects and that most infections were mild and in the upper respiratory tract. Here, TNF is linked to infection.