Thrombosis is a type of CVD complication that may also occur in the setting of other diseases such as diabetes, cirrhosis, end-stage renal disease, myocardial infarction etc. Fibrinogen plays a vital role in the development of thrombosis by acquiring so-called “thrombogenic” characteristics: increased concentration, reduced porosity of formed fibrin usually with thinner and more densely packed fibrin fibrils and an increased resistance to plasmin proteolysis [132]. Here, PLG is linked to diabetes mellitus.