In the first model, including all candidates’ predictors, except LA, creatinine at peak (hazard ratio (HR) 1.01, confidence interval (CI) 95% [1.00–1.02], p = 0.011), CRP at peak (HR 1.00, CI95% [1.00–1.01], p = 0.012) and COVID-19 (HR 4.19, CI95% [1.27–13.76], p = 0.018) were independent predictors of transfer to the ICU in patients with APE. Here, CRP is linked to COVID-19.