The perioperative predictors of an ER such as the tumor size [6,7,8], metastases in the harvested lymph nodes [6,7,8], the serum carbohydrate antigen 19-9 (CA19-9) value [6,9,10,11,12], the duration of symptoms [13], a modified Glasgow Prognostic Score [14], a Charlson age-comorbidity index [6], tumor differentiation [6,12,13] and p53 expression in the primary tumor [15] have been reported to identify high-risk patients. The gene discussed is TP53; the disease is neoplasm.