WDR41 and early-onset autosomal dominant Alzheimer disease: Importantly, several variants in WDR41 have been identified in previous GWAS having near genome-wide significant association signals for: Alzheimer’s disease (AD) (p = 7 × 10−7) [22]; caudate nucleus volume (p = 2 × 10−7), where caudate is a subcortical brain structure implicated in many common neurological and psychiatric disorders [23]; and epileptogenesis (p = 5 × 10−6) [24] in European populations.