CRHR1 and nervous system disorder: Overall, the novel individual association signals in TEKT4 and WDR41 and the SNP–SNP interaction effect in CRHR1 identified in this study are important because although TEKT4 and WDR41 have not previously been reported to be associated with PD, previous findings indicate the possible associations of these genes with several neurogenerative and neurological disorders, making them strong biological candidates due to their established pleiotropy.