CD274 and neoplasm: More in particular, according to the results of the Keynote 048 trial, when pembrolizumab was used alone versus the standard cisplatin-5fluorouracil-cetuximab scheme, patients whose tumor did express high level of tissue PDL-1, experienced a significantly higher OS if compared with standard chemotherapy (14.9 vs. 10.7 months, p < 0.0086).