For example, NFAT5 can regulate thermogenesis and obesity by recruiting DNMT1 to the promoter of b3-adrenoceptor, a key regulator in thermogenesis and obesity, resulting in the suppression of thermogenesis and the beiging of white adipose tissue, leading to obesity and insulin resistance [19]. The gene discussed is NFAT5; the disease is obesity due to melanocortin 4 receptor deficiency.