NFAT5 and infection: In addition, the authors noticed enhanced IFN-I production and viral clearance upon lymphocytic choriomeningitis virus (LCMV) infection in mice lacking Nfat5. Furthermore, infection of Nfat5-deficient macrophages (BMDMs) and GM-CSF-induced conventional bone marrow-derived myeloid DCs (GM-BMDCs) with VSV or murine CMV (MCMV) also showed higher expression levels of IFNB1.