BAK1 and cancer: Since it is known that BA induces apoptosis in cancer cells via the intrinsic pathway involving mitochondria and the data regarding the role played by the pro- and anti-apoptotic markers in this process is still debatable, we further verified the effect of BA on pro-apoptotic (Bid, Bax, Bak, and Bad) and anti-apoptotic markers (Bcl-2 and Bcl-XL) mRNA expression (Figure 7).