BCL2L1 and cancer: Studies performed over the past decade stated that BA inhibits the growth and induces apoptosis in multiple human cancer cell lines, several mechanisms being reported here: (i) the induction of apoptosis in a caspases activation dependent manner, correlated with an upregulation of the pro-apoptotic proteins of Bcl-2 (B-cell lymphoma 2) family, Bax and Bcl-xs [18]; (ii) the activation of p38 and SAP/JNK (pro-apoptotic MAPK subgroups), with the involvement of ROS upstream of MAPK response [19], and (iii) the induction of ROS generation [14].