Indeed, a previous study showed that 7,12-dimethylbenzanthrancene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) were frequently used as a cSCC initiator and promoter respectively in a mouse model [5], and p53-deficiency in epidermis contributes to the development of the tumor size of SCC by this DMBA/TPA treatment SCC model [6]. Here, TP53 is linked to skin squamous cell carcinoma.