Recent studies identified that CADM1 was closely related to the development or regulation of skin cancers [9], such as SCC [25], malignant melanoma [27], adult T-cell leukemia/lymphoma [28], mycosis fungoides [17,29], Sézary Syndrome [30], and Merkel cell carcinoma [31]. The gene discussed is CADM1; the disease is Merkel cell skin cancer.