In addition, melatonin ameliorates oxidative stress during cardiac hypertrophy and cardio/cerebral ischemia-reperfusion in a RORα-dependent manner, with beneficial effects on pathological cardiac hypertrophy, myocardial infarction, ischemic stroke, and diabetic cardiomyopathy [12,36,37,38]. This evidence concerns the gene RORA and diabetic cardiomyopathy.