Short interfering RNAs downregulating the expression of epidermal growth factor receptors have been shown to enhance the chemosensitivity of well-established anticancer compounds (cisplatin, 5-fluorouracil, and docetaxel) [31] and radiosensitivity [32] in various cancer cells, including head and neck squamous cell carcinoma (HNSCCs). Here, EGFR is linked to cancer.