It contributes to disease progression by stimulating proliferation and invasion in a multitude of different tumor entities [24,25,26,27,28] via the activation of several tumor-related pathways like ERK and TNFR2/Akt signaling [29,30,31,32] and PI3K [32] or Wnt [33] signaling. Here, TNFRSF1B is linked to neoplasm.